Borussertib

Catalog No. A13364

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.

Technical details

Catalog Num	A13364
M. Wt	596.68
Formula	C36H32N6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1800070-77-2
Synonyms
SMILES	C=CC(NC1=CC=C(N2)C(N(C3CCN(CC4=CC=C(C5=NC6=C(C(NC=C6)=O)C=C5C7=CC=CC=C7)C=C4)CC3)C2=O)=C1)=O

Biological Activity

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.

Solubility *

In vitro	DMSO	95 mg/mL (159.21 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.76 mL	83.8 mL	167.59 mL
0.5 mM	3.35 mL	16.76 mL	33.52 mL
1 mM	1.68 mL	8.38 mL	16.76 mL
5 mM	0.34 mL	1.68 mL	3.35 mL

*The above data is based on the productmolecular weight 596.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Borussertib

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions