PF-4

Catalog No. A13451

PFI-4是一种有效的，选择性的且细胞可渗透的BRPF1溴结构域抑制剂（IC50 = 80 nM）。相对于包括BRPF2（BRD1），BRPF3和BRD4在内的其他溴结构域，BRPF1的选择性> 100倍。

Technical details

Catalog Num	A13451
M. Wt	380.44
Formula	C21H24N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	900305-37-5
Synonyms	PF4, PF 4
SMILES	[H]N(C(C1=CC=CC=C1OC)=O)C2=C(N3CCCC3)C=C(N(C)C(N4C)=O)C4=C2

Biological Activity

Targets

BRPF1	BRPF2	BRPF3
80 nM	7.9 μM	>10μM

Solubility *

In vitro	DMSO	Warmed: 17 mg/mL (44.68 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (13.14 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.43 mL	262.85 mL
0.5 mM	5.26 mL	26.29 mL	52.57 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.