Brexpiprazole

Catalog No. A13527

Brexpiprazole是一种新型的D2多巴胺部分激动剂研究产品，目前正在临床试验中，用于治疗抑郁症，精神分裂症和注意缺陷多动障碍（ADHD）。

Technical details

Catalog Num	A13527
M. Wt	433.5733
Formula	C25H27N3O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	913611-97-9
Synonyms	OPC 34712, OPC-34712
SMILES	C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4

Biological Activity

Brexpiprazole是一种新型的D2多巴胺部分激动剂研究产品，目前正在临床试验中，用于治疗抑郁症，精神分裂症和注意缺陷多动障碍（ADHD）。

Targets

5-HT1A	human noradrenergic α1B	Dopamine D2L	5-HT2A receptors	α2C receptors
0.12 nM(Ki)	0.17 nM(Ki)	0.3 nM(Ki)	0.47 nM(Ki)	0.59 nM(Ki)

Solubility *

In vitro	DMSO	21 mg/mL (48.43 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.06 mL	115.32 mL	230.64 mL
0.5 mM	4.61 mL	23.06 mL	46.13 mL
1 mM	2.31 mL	11.53 mL	23.06 mL
5 mM	0.46 mL	2.31 mL	4.61 mL

*The above data is based on the productmolecular weight 433.5733. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.