FRAX486

Catalog No. A13691

FRAX486是一种小分子PAK抑制剂。

Product Citations

Yukie Yamahashi, .et al. Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning, Mol Psychiatry, 2022, 03 June

Technical details

Catalog Num	A13691
M. Wt	513.39
Formula	C25H23Cl2FN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1232030-35-1
Synonyms	FRAX 486, FRAX-486
SMILES	CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F

Biological Activity

FRAX486是一种小分子PAK抑制剂。

Targets

PAK1	PAK2	PAK3	PAK4
14 nM	33 nM	39 nM	575 nM

Solubility *

In vitro	DMSO	21 mg/mL (40.9 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.48 mL	97.39 mL	194.78 mL
0.5 mM	3.9 mL	19.48 mL	38.96 mL
1 mM	1.95 mL	9.74 mL	19.48 mL
5 mM	0.39 mL	1.95 mL	3.9 mL

*The above data is based on the productmolecular weight 513.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.