GNE-7915

Catalog No. A13748

GNE-7915是一种富含亮氨酸重复激酶2（LRRK2）的血脑屏障（BBB）渗透性小分子抑制剂。

Technical details

Catalog Num	A13748
M. Wt	443.395
Formula	C19H21F4N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1351761-44-8
Synonyms	GNE7915, GMS 7915
SMILES	CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

Biological Activity

GNE-7915是一种富含亮氨酸重复激酶2（LRRK2）的血脑屏障（BBB）渗透性小分子抑制剂。

Targets

LRRK2	LRRK2
1 nM(Ki)	9 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 21 mg/mL (47.36 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.77 mL	225.53 mL
0.5 mM	4.51 mL	22.55 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.395. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.