AdipoRon

Catalog No. A13768

AdipoRon是一种新型的小分子AdipoR激动剂；与AdipoR1（Kd = 1.8 uM）和AdipoR2（Kd = 3.1 uM）绑定；IC50值：1.8/3.1 uM（AdipoR1/2，Kd）。

Product Citations

Yunjing Yan, .et al. Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen-activated protein kinase, J Pathol, 2022, Jun;257(2):146-157 PMID: 35072951
Uchida T, .et al. The Neuroprotective Effect of the Adiponectin Receptor Agonist AdipoRon on Glutamate-Induced Cell Death in Rat Primary Retinal Ganglion Cells, J Ocul Pharmacol Ther, 2019, Aug 28 PMID: 31460821

Technical details

Catalog Num	A13768
M. Wt	428.52
Formula	C27H28N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	924416-43-3
Synonyms
SMILES	C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4

Biological Activity

AdipoRon是一种新型的小分子AdipoR激动剂；与AdipoR1（Kd = 1.8 uM）和AdipoR2（Kd = 3.1 uM）绑定；IC50值：1.8/3.1 uM（AdipoR1/2，Kd）。

Targets

AdipoR1	AdipoR2
1.8 μM(Kd)	3.1 μM(Kd)

Solubility *

In vitro	DMSO	77 mg/mL (179.69 mM)
	Water	Insoluble
	Ethanol	45 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.68 mL	233.36 mL
0.5 mM	4.67 mL	23.34 mL	46.67 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.