PX 12

Catalog No. A13831

PX 12抑制缺氧诱导的HIF-1a转录活性（IC50 11 nM）和HT29和MCF-7肿瘤细胞的增殖（IC50分别为1.9和0.9 uM）。

Technical details

Catalog Num	A13831
M. Wt	188.31
Formula	C7H12N2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	141400-58-0
Synonyms	IV-2, PX-12, PX12
SMILES	CCC(C)SSC1=NC=CN1

Biological Activity

PX 12抑制缺氧诱导的HIF-1a转录活性（IC50 11 nM）和HT29和MCF-7肿瘤细胞的增殖（IC50分别为1.9和0.9 uM）。

Targets

Trx-1

Solubility *

In vitro (25°C)	DMSO	37 mg/mL (196.48 mM)
	Water	Insoluble
	Ethanol	37 mg/mL
In vivo	2% DMSO+30% PEG 300+ddH2O	10 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	53.1 mL	265.52 mL	531.04 mL
0.5 mM	10.62 mL	53.1 mL	106.21 mL
1 mM	5.31 mL	26.55 mL	53.1 mL
5 mM	1.06 mL	5.31 mL	10.62 mL

*The above data is based on the productmolecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.