TP-434 (Eravacycline)
Catalog No. A13887
TP-434 (Eravacycline)是一种新型的广谱氟环素抗生素，对表达主要抗生素抗性机制（包括四环素特异性外排和核糖体保护）的细菌具有活性。
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
- Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
| Catalog Num | A13887 |
|---|---|
| M. Wt | 558.555 |
| Formula | C27H31FN4O8 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1207283-85-9 |
| Synonyms | Eravacycline, TP434, TP 434 |
| SMILES | CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F |
TP-434 (Eravacycline)是一种新型的广谱氟环素抗生素，对表达主要抗生素抗性机制（包括四环素特异性外排和核糖体保护）的细菌具有活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.9 mL | 89.52 mL | 179.03 mL |
| 0.5 mM | 3.58 mL | 17.9 mL | 35.81 mL |
| 1 mM | 1.79 mL | 8.95 mL | 17.9 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.555. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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