3-deazaneplanocin A HCl (DZNep HCl)

Catalog No. A13947

3-deazaneplanocin A，也称为DZNep，是众所周知的组蛋白甲基转移酶抑制剂，可破坏包括急性髓样白血病，乳腺癌在内的癌细胞中的多梳抑制复合物2（PRC2），并诱导细胞凋亡，同时抑制增殖和转移。癌症和胶质母细胞瘤。

Technical details

Catalog Num	A13947
M. Wt	298.73
Formula	C12H15ClN4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	120964-45-6
Synonyms	DZNep, NSC 617989
SMILES	C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N.Cl

Biological Activity

Targets

S-adenosylhomocysteine hydrolase ()
50 pM(Ki)

Solubility *

In vitro (25°C)	DMSO	49 mg/mL (164.03 mM)
	Water	49 mg/mL (164.03 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.48 mL	167.38 mL	334.75 mL
0.5 mM	6.7 mL	33.48 mL	66.95 mL
1 mM	3.35 mL	16.74 mL	33.48 mL
5 mM	0.67 mL	3.35 mL	6.7 mL

*The above data is based on the productmolecular weight 298.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.