NK314
Catalog No. A13993
NK314是一种新型的合成苯并[c]菲啶生物碱，具有很强的抗肿瘤活性。它抑制拓扑异构酶II活性并稳定拓扑异构酶II-DNA可裂解的复合物。
- Kopa P, .et al. Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells, Mol Biol Rep, 2019, Oct 3 PMID: 31583565
- Macieja A, .et al. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors, Mol Biol Rep, 2019, Apr 24 PMID: 31020489
| Catalog Num | A13993 |
|---|---|
| M. Wt | 395.83 |
| Formula | C22H18ClNO4 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 208237-49-4 |
| Synonyms | NK-314, NK 314 |
| SMILES | OC1=C(OC)C=CC2=C(C=CC3C4C=C5C(OCO5)=C3)C4=[N+]6C(CCC6)=C12.[Cl-] |
NK314是一种新型的合成苯并[c]菲啶生物碱，具有很强的抗肿瘤活性。它抑制拓扑异构酶II活性并稳定拓扑异构酶II-DNA可裂解的复合物。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.26 mL | 126.32 mL | 252.63 mL |
| 0.5 mM | 5.05 mL | 25.26 mL | 50.53 mL |
| 1 mM | 2.53 mL | 12.63 mL | 25.26 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.05 mL |
*The above data is based on the productmolecular weight 395.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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