DMOG

Catalog No. A13998

DMOG是HIF-PH的细胞渗透性竞争性抑制剂。它可在正常的氧气张力下（0.1至1 mM的浓度）稳定HIF-1α表达。

Product Citations

Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367

Technical details

Catalog Num	A13998
M. Wt	175.14
Formula	C6H9NO5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	89464-63-1
Synonyms	Dimethyloxaloyl glycine
SMILES	COC(=O)CNC(=O)C(=O)OC

Biological Activity

DMOG是HIF-PH的细胞渗透性竞争性抑制剂。它可在正常的氧气张力下（0.1至1 mM的浓度）稳定HIF-1α表达。

Targets

HIF prolyl hydroxylase

Solubility *

In vitro	DMSO	33 mg/mL (188.42 mM)
	Water	33 mg/mL (188.42 mM)
	Ethanol	33 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	57.1 mL	285.49 mL	570.97 mL
0.5 mM	11.42 mL	57.1 mL	114.19 mL
1 mM	5.71 mL	28.55 mL	57.1 mL
5 mM	1.14 mL	5.71 mL	11.42 mL

*The above data is based on the productmolecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.