Tenapanor
Catalog No. A14011
Tenapanor充当钠-质子交换器NHE3的抑制剂。这种抗转运蛋白在肾脏和肠道中发现，通常起到调节机体吸收和分泌的钠水平的作用。
- Xingjie Tan, .et al. The Na+/H+ exchanger NHE3 inhibitor tenapanor prevents intestinal obstructions in CFTR-deleted mice, Authorea, 2022, May 25
- Kunyan Zhou, .et al. Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells, Am J Physiol Cell Physiol, 2021, Sep 1;321(3):C471-C488 PMID: 34288721
- Qinghai Tan, .et al. Inhibition of Na + /H + exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator-deficient and F508del mutant mice, Br J Pharmacol, 2021, Mar;178(5):1018-1036 PMID: 33179259
- Y Liu, .et al. Deciphering Ion Transporters, Kinases and PDZ-adaptor Molecules That Mediate Guanylate Cyclase C Agonist-Dependent Intestinal Fluid Loss in Vivo, Biochem Pharmacol, 2020, May 16;178:114040 PMID: 32422138
- Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
- Thammayon N, .et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 PMID: 27981415
- Charoenphandhu N, .et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 PMID: 27995414
- Jantarajit W, .et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 PMID: 28490422
| Catalog Num | A14011 |
|---|---|
| M. Wt | 1145.0614 |
| Formula | C50H66Cl4N8O10S2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1234423-95-0 |
| Synonyms | AZD1722, RDX5791 |
| SMILES | CN1C[C@H](C2=CC(=CC(=C2C1)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[C@@H]5CN(CC6=C(C=C(C=C56)Cl)Cl)C |
Tenapanor充当钠-质子交换器NHE3的抑制剂。这种抗转运蛋白在肾脏和肠道中发现，通常起到调节机体吸收和分泌的钠水平的作用。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.73 mL | 43.67 mL | 87.33 mL |
| 0.5 mM | 1.75 mL | 8.73 mL | 17.47 mL |
| 1 mM | 0.87 mL | 4.37 mL | 8.73 mL |
| 5 mM | 0.17 mL | 0.87 mL | 1.75 mL |
*The above data is based on the productmolecular weight 1145.0614. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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