BAPTA/AM

Catalog No. A14023

BAPTA/AM是一种细胞内钙螯合剂，可通过脂氧合酶介导的自由基在小鼠皮层培养物中诱导延迟性坏死。

Product Citations

Liying Wu, .et al. Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy-lysosome mediated OCT4A degradation, Phytother Res, 2022, Feb;36(2):938-950 PMID: 35076979
Shichen Xu, .et al. Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload, Cell Signal, 2020, Aug 6;75:109733 PMID: 32771398
Miho Akimoto, .et al. Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis, Cell Death Dis, 2018, Aug; 9(8): 804 PMID: 30038429
Zhang L, .et al. Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis, Medicine (Baltimore), 2018, Jun;97(24):e11095 PMID: 29901626

Technical details

Catalog Num	A14023
M. Wt	764.68
Formula	C34H40N2O18
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	126150-97-8
Synonyms	BAPTA-AM, BAPTA AM
SMILES	CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

Biological Activity

BAPTA/AM是一种细胞内钙螯合剂，可通过脂氧合酶介导的自由基在小鼠皮层培养物中诱导延迟性坏死。

Targets

Solubility *

In vitro	DMSO	19 mg/mL (24.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.08 mL	65.39 mL	130.77 mL
0.5 mM	2.62 mL	13.08 mL	26.15 mL
1 mM	1.31 mL	6.54 mL	13.08 mL
5 mM	0.26 mL	1.31 mL	2.62 mL

*The above data is based on the productmolecular weight 764.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.