ONX 0912 (Oprozomib)

Catalog No. A14181

ONX 0912 (Oprozomib)是一种三肽环氧酮，可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。

Technical details

Catalog Num	A14181
M. Wt	532.2
Formula	C25H32N4O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	935888-69-0
Synonyms	Oprozomib,ONX-0912,ONX0912
SMILES	CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C

Biological Activity

ONX 0912 (Oprozomib)是一种三肽环氧酮，可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。

Targets

20S proteasome β5	20S proteasome LMP7
36 nM	82 nM

Solubility *

In vitro	DMSO	86 mg/mL (161.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.79 mL	93.95 mL	187.9 mL
0.5 mM	3.76 mL	18.79 mL	37.58 mL
1 mM	1.88 mL	9.39 mL	18.79 mL
5 mM	0.38 mL	1.88 mL	3.76 mL

*The above data is based on the productmolecular weight 532.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.