AZD-3965

Catalog No. A14186

AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。

Product Citations

Lu Gao, .et al. Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy, Int J Biol Sci, 2022, Jan 1;18(2):599-616 PMID: 35002512

Technical details

Catalog Num	A14186
M. Wt	515.5
Formula	C21H24F3N5O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1448671-31-5
Synonyms	AZD3965,AZD 3965
SMILES	O=C1N(C(C)C)C2=C(C(C(N3OC[C@@](C)(O)C3)=O)=C(CC4=C(C(F)(F)F)NN=C4C)S2)C(N1C)=O

Biological Activity

AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。

Targets

MCT1

Solubility *

In vitro	DMSO	96 mg/mL (186.22 mM)
	Water	Insoluble
	Ethanol	96 mg/mL (186.22 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.4 mL	96.99 mL	193.99 mL
0.5 mM	3.88 mL	19.4 mL	38.8 mL
1 mM	1.94 mL	9.7 mL	19.4 mL
5 mM	0.39 mL	1.94 mL	3.88 mL

*The above data is based on the productmolecular weight 515.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.