SRT2104 (GSK2245840)

Catalog No. A14188

SRT2104 (GSK2245840)是一种选择性sirt1激活剂，参与能量稳态的调节。

Product Citations

Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
Liu X, .et al. Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats, Life Sci, 2019, Nov 9:117041 PMID: 31715188

Technical details

Catalog Num	A14188
M. Wt	516.64
Formula	C26H24N6O2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1093403-33-8
Synonyms
SMILES	CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CN5C(=CSC5=N4)CN6CCOCC6

Biological Activity

SRT2104 (GSK2245840)是一种选择性sirt1激活剂，参与能量稳态的调节。

Targets

SIRT1

Solubility *

In vitro	DMSO	Warmed: 5 mg/mL (9.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.36 mL	96.78 mL	193.56 mL
0.5 mM	3.87 mL	19.36 mL	38.71 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

*The above data is based on the productmolecular weight 516.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.