Tiplaxtinin (PAI-039)

Catalog No. A14190

Tiplaxtinin (PAI-039)是一种纤溶酶原激活物抑制剂1（PAI-1）的选择性口服有效抑制剂，IC50为2.7μM。

Product Citations

Saijo A, .et al. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells, Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000

Technical details

Catalog Num	A14190
M. Wt	439.3833
Formula	C24H16F3NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	393105-53-8
Synonyms	PAI-039
SMILES	C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O

Biological Activity

Tiplaxtinin (PAI-039)是一种纤溶酶原激活物抑制剂1（PAI-1）的选择性口服有效抑制剂，IC50为2.7μM。

Targets

PAI-1
2.7 μM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (141.1 mM)
	Water	Insoluble
	Ethanol	Warmed: 15 mg/mL (34.13 mM)
In vivo	2.0% Tween 80+0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.76 mL	113.8 mL	227.59 mL
0.5 mM	4.55 mL	22.76 mL	45.52 mL
1 mM	2.28 mL	11.38 mL	22.76 mL
5 mM	0.46 mL	2.28 mL	4.55 mL

*The above data is based on the productmolecular weight 439.3833. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.