IM-12

Catalog No. A14196

IM-12是一种细胞渗透性吲哚标记，作为糖原合成酶激酶3β（GSK-3β）抑制剂，激活典型Wnt信号的下游成分。

Technical details

Catalog Num	A14196
M. Wt	377.41
Formula	C22H20FN3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1129669-05-1
Synonyms	IM12, IM 12
SMILES	CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F

Biological Activity

IM-12是一种细胞渗透性吲哚标记，作为糖原合成酶激酶3β（GSK-3β）抑制剂，激活典型Wnt信号的下游成分。

Targets

GSK-3β
53 nM

Solubility *

In vitro	DMSO	72 mg/mL (190.77 mM)
	Water	Insoluble
	Ethanol	Warmed: 10 mg/mL (26.49 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.5 mL	132.48 mL	264.96 mL
0.5 mM	5.3 mL	26.5 mL	52.99 mL
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL

*The above data is based on the productmolecular weight 377.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.