Edoxaban (tosylate Monohydrate)

Catalog No. A14317

Edoxaban (tosylate Monohydrate)是选择性Factor Xa抑制剂，Ki为0.561 nM。

Product Citations

Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343

Technical details

Catalog Num	A14317
M. Wt	738.27
Formula	C24H30ClN7O4S.C7H8O3S.H2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1229194-11-9
Synonyms	DU-176b
SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O

Biological Activity

Edoxaban (tosylate Monohydrate)是选择性Factor Xa抑制剂，Ki为0.561 nM。

Targets

Factor Xa	Thrombin	FIXa
0.561 nM(Ki)	6 μM(Ki)	41.7 μM(Ki)

Solubility *

In vitro	DMSO	89 mg/mL (120.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.55 mL	67.73 mL	135.45 mL
0.5 mM	2.71 mL	13.55 mL	27.09 mL
1 mM	1.35 mL	6.77 mL	13.55 mL
5 mM	0.27 mL	1.35 mL	2.71 mL

*The above data is based on the productmolecular weight 738.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.