GSK591

Catalog No. A14374

GSK591是精氨酸甲基转移酶PRMT5的有效选择性抑制剂，IC50为11 nM。

Technical details

Catalog Num	A14374
M. Wt	380.48
Formula	C22H28N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1616391-87-7
Synonyms	EPZ015866,GSK3203591
SMILES	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4CCC4)=NC=C3

Biological Activity

GSK591是精氨酸甲基转移酶PRMT5的有效选择性抑制剂，IC50为11 nM。

Targets

PRMT5
4nM

Solubility *

In vitro	DMSO	75 mg/mL (197.11 mM)
	Water	Insoluble
	Ethanol	75 mg/mL (197.11 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.28 mL	131.41 mL	262.83 mL
0.5 mM	5.26 mL	26.28 mL	52.57 mL
1 mM	2.63 mL	13.14 mL	26.28 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.