Ro 3306

Catalog No. A14437

Ro 3306是一种具有ATP竞争能力的有效细胞周期蛋白依赖性激酶（cdk）1抑制剂（cdk1/cyclin B1和cdk1/cyclin A的Ki值分别为35和110 nM。

Product Citations

Jianming Wang, .et al. Protocol for analysis of G2/M DNA synthesis in human cells, STAR Protoc, 2021, May 29;2(2):100570 PMID: 34136835
Jianming Wang, .et al. Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M, Cell Rep, 2021, Feb 16;34(7):108759 PMID: 33596418

Technical details

Catalog Num	A14437
M. Wt	351.45
Formula	C18H13N3OS2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	872573-93-8
Synonyms	Ro3306, Ro-3306
SMILES	C1=CC2=C(C=CC(=C2)/C=C/3\C(=O)N=C(S3)NCC4=CC=CS4)N=C1

Biological Activity

Ro 3306是一种具有ATP竞争能力的有效细胞周期蛋白依赖性激酶（cdk）1抑制剂（cdk1/cyclin B1和cdk1/cyclin A的Ki值分别为35和110 nM。

Targets

Target	Value
CDK1	ki: 20nM
PKCδ	ki: 318nM
SGK	ki: 497nM
ERK	ki: 1980nM
PKA	ki: >2000nM
Akt	ki: >2000nM
PKCα	ki: >2000nM
Fyn	ki: >2000nM
EphB3	ki: >2000nM

Solubility *

In vitro	DMSO	Warmed: 12 mg/mL (34.14 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.45 mL	142.27 mL	284.54 mL
0.5 mM	5.69 mL	28.45 mL	56.91 mL
1 mM	2.85 mL	14.23 mL	28.45 mL
5 mM	0.57 mL	2.85 mL	5.69 mL

*The above data is based on the productmolecular weight 351.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.