U-104

Catalog No. A14959

U-104是碳酸酐酶IX（CAIX）的新型脲基磺酰胺抑制剂。

Technical details

Catalog Num	A14959
M. Wt	309.32
Formula	C13H12FN3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	178606-66-1
Synonyms	NSC 213841, U 104, U104
SMILES	C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F

Biological Activity

U-104是碳酸酐酶IX（CAIX）的新型脲基磺酰胺抑制剂。

Targets

CAXII	CAIX	CAI	CAII
4.5 nM(Ki)	45.1 nM(Ki)	5.08 μM(Ki)	9.64 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	60 mg/mL (193.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.33 mL	161.64 mL	323.29 mL
0.5 mM	6.47 mL	32.33 mL	64.66 mL
1 mM	3.23 mL	16.16 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL

*The above data is based on the productmolecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.