Afatinib dimaleate
Catalog No. A14985
Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂,对于HER2的体外药效IC50为14 nM。
Catalog Num | A14985 |
---|---|
M. Wt | 718.08 |
Formula | C32H33ClFN5O11 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 850140-73-7 |
Synonyms | BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib |
SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O |
Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂,对于HER2的体外药效IC50为14 nM。
Targets
EGFR (L858R) | EGFR (wt) | EGFR (L858R/T790M) | HER2 | |
0.4 nM | 0.5 nM | 10 nM | 14 nM |
In vitro (25°C) | DMSO | 87 mg/mL (121.3 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+30% PEG 300+ddH2O | 26 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 13.93 mL | 69.63 mL | 139.26 mL |
0.5 mM | 2.79 mL | 13.93 mL | 27.85 mL |
1 mM | 1.39 mL | 6.96 mL | 13.93 mL |
5 mM | 0.28 mL | 1.39 mL | 2.79 mL |
*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.