ROCK inhibitor

Catalog No. A15225

ROCK inhibitor是人类ROCK-1和ROCK-2同工酶的高效抑制剂，IC50值分别为0.6和1.1 nM。

Product Citations

Nina Seidelmann, .et al. Human platelet lysate as a replacement for fetal bovine serum in human corneal stromal keratocyte and fibroblast culture, J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211

Technical details

Catalog Num	A15225
M. Wt	402.79
Formula	C18H13ClF2N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	867017-68-3
Synonyms	Rho-kinase inhibitor, Rho Kinase Inhibitor, ROCK
SMILES	CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F

Biological Activity

ROCK inhibitor是人类ROCK-1和ROCK-2同工酶的高效抑制剂，IC50值分别为0.6和1.1 nM。

Solubility *

In vitro	DMSO	77 mg/mL (191.16 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.96 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.83 mL	124.13 mL	248.27 mL
0.5 mM	4.97 mL	24.83 mL	49.65 mL
1 mM	2.48 mL	12.41 mL	24.83 mL
5 mM	0.5 mL	2.48 mL	4.97 mL

*The above data is based on the productmolecular weight 402.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.