SEA0400

Catalog No. A15236

SEA0400是Na+-Ca2+交换剂的新型选择性抑制剂，IC50为5-33 nM（抑制培养的神经元，星形胶质细胞和小胶质细胞中Na+依赖的Ca2+吸收。

Product Citations

Wakana Shoda, .et al. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia, PLoS One, 2020, 15(6): e0235360 PMID: 32603346

Technical details

Catalog Num	A15236
M. Wt	371.38
Formula	C21H19F2NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	223104-29-8
Synonyms	SEA 0400, SEA-0400
SMILES	CCOC1=CC(=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(=C3)F)F)N

Biological Activity

SEA0400是Na+-Ca2+交换剂的新型选择性抑制剂，IC50为5-33 nM（抑制培养的神经元，星形胶质细胞和小胶质细胞中Na+依赖的Ca2+吸收。

Solubility *

In vitro	DMSO	63 mg/mL (169.63 mM)
	Water	Insoluble
	Ethanol	63 mg/mL (169.63 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.93 mL	134.63 mL	269.27 mL
0.5 mM	5.39 mL	26.93 mL	53.85 mL
1 mM	2.69 mL	13.46 mL	26.93 mL
5 mM	0.54 mL	2.69 mL	5.39 mL

*The above data is based on the productmolecular weight 371.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.