SRT 1720
Catalog No. A15247
SRT 1720是人类SIRT1（EC1.5 = 0.16μM）相对于最接近的瑟土因同系物SIRT2和SIRT3（SIRT2：EC1.5 = 37 uM；SIRT3：EC1.5> 300 uM）的选择性激活剂。
- A Khader ,etc. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion. Transplantation, 2014, 98(2), 148-156.
- BD Rowlands ,etc. SIRT1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism while SRT1720 increases oxidative metabolism. , 2015, 93:1147-1156.
- BD Rowlands ,etc. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism. Journal of neuroscience research, 2015, 93(7), 1147-1156.
- A Khader ,etc. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy. Critical care medicine, 2016, 44(8), e651-e663.
- BD Rowlands ,etc. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation. Journal of Neurochemistry, 2016, 140(6):903-918. .
| Catalog Num | A15247 |
|---|---|
| M. Wt | 469.56 |
| Formula | C25H23N7OS |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 925434-55-5 |
| Synonyms | SRT-1720, SRT1720 |
| SMILES | C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5 |
SRT 1720是人类SIRT1（EC1.5 = 0.16μM）相对于最接近的瑟土因同系物SIRT2和SIRT3（SIRT2：EC1.5 = 37 uM；SIRT3：EC1.5> 300 uM）的选择性激活剂。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.3 mL | 106.48 mL | 212.97 mL |
| 0.5 mM | 4.26 mL | 21.3 mL | 42.59 mL |
| 1 mM | 2.13 mL | 10.65 mL | 21.3 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
*The above data is based on the productmolecular weight 469.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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