XL-147 (Pilaralisib)

Catalog No. A15283

XL-147 (Pilaralisib)是I类PI3K脂质激酶家族有效的生物利用抑制剂。

Technical details

Catalog Num	A15283
M. Wt	541.02
Formula	C25H25ClN6O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	934526-89-3
Synonyms	SAR245408, XL 147, XL147, SAR-245408, SAR 245408, pilaralisib
SMILES	CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N

Biological Activity

XL-147 (Pilaralisib)是I类PI3K脂质激酶家族有效的生物利用抑制剂。

Targets

PI3Kγ	PI3Kβ	PI3Kδ	PI3Kα
23 nM	36 nM	36 nM	39 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 92 mg/mL (170.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	10 mM HCl in sterile water	0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.48 mL	92.42 mL	184.84 mL
0.5 mM	3.7 mL	18.48 mL	36.97 mL
1 mM	1.85 mL	9.24 mL	18.48 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 541.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.