b-AP15 (NSC 687852)

Catalog No. A15391

b-AP15 (NSC 687852)是两种与蛋白酶体相关的DUBs的泛素特异性加工蛋白酶14（USP14）和泛素羧基末端水解酶同工酶L5（UCHL5）的抑制剂。

Product Citations

Anurag Rathore, .et al. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models, Sci Rep, 2020, 10: 5350 PMID: 32210344

Technical details

Catalog Num	A15391
M. Wt	419.39
Formula	C22H17N3O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1009817-63-3
Synonyms	b-AP15
SMILES	C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1

Biological Activity

b-AP15 (NSC 687852)是两种与蛋白酶体相关的DUBs的泛素特异性加工蛋白酶14（USP14）和泛素羧基末端水解酶同工酶L5（UCHL5）的抑制剂。

Targets

USP14	UCHL5
N/A	2.1 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 42 mg/mL (100.14 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.84 mL	119.22 mL	238.44 mL
0.5 mM	4.77 mL	23.84 mL	47.69 mL
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.