Elafibranor

Catalog No. A15454

Elafibranor是过氧化物酶体增殖物激活的受体-α和-δ的激动剂，可诱导非酒精性脂肪性肝炎消退，而不会使纤维化恶化。

Product Citations

Joost Boeckmans, .et al. Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery, Cells, 2022, 11(5), 893 PMID: 35269515
Tomasz Kostrzewski, .et al. Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system, Commun Biol, 2021, 4: 1080 PMID: 34526653
Joost Boeckmans, .et al. Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH, MethodsX, 2020, 7: 101068 PMID: 33024711
Joost Boeckmans, .et al. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists, Cell Biol Toxicol, 2020, Jul 1 PMID: 32613381
Joost Boeckmans, .et al. Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor, Data in Brief, 2019, June 3 PMID: 31294056
Boeckmans J, .et al. Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH, Pharmacol Res, 2019, Apr 24. pii: S1043-6618(18)31850-4 PMID: 31028903

Technical details

Catalog Num	A15454
M. Wt	384.49
Formula	C22H24O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	923978-27-2
Synonyms	GFT505, GFT-505, GFT 505
SMILES	CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)C=CC(=O)C2=CC=C(C=C2)SC

Biological Activity

Elafibranor是过氧化物酶体增殖物激活的受体-α和-δ的激动剂，可诱导非酒精性脂肪性肝炎消退，而不会使纤维化恶化。

Solubility *

In vitro	DMSO	74 mg/mL (192.46 mM)
	Water	Insoluble
	Ethanol	74 mg/mL (192.46 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.01 mL	130.04 mL	260.08 mL
0.5 mM	5.2 mL	26.01 mL	52.02 mL
1 mM	2.6 mL	13 mL	26.01 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.