TH287

Catalog No. A15536

TH287是一种有效的MTH1（NUDT1）抑制剂，IC50值为0.8 nM，对MTH2，NUDT5，NUDT12，NUDT14和NUDT16的效力较低。

Technical details

Catalog Num	A15536
M. Wt	269.13
Formula	C11H10Cl2N4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1609960-30-6
Synonyms	TH-287, TH 287
SMILES	CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N

Biological Activity

TH287是一种有效的MTH1（NUDT1）抑制剂，IC50值为0.8 nM，对MTH2，NUDT5，NUDT12，NUDT14和NUDT16的效力较低。

Targets

MTH1 (NUDT1)
0.8 nM

Solubility *

In vitro	DMSO	48 mg/mL (178.35 mM)
	Water	Insoluble
	Ethanol	Warmed: 9 mg/mL (33.44 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.16 mL	185.78 mL	371.57 mL
0.5 mM	7.43 mL	37.16 mL	74.31 mL
1 mM	3.72 mL	18.58 mL	37.16 mL
5 mM	0.74 mL	3.72 mL	7.43 mL

*The above data is based on the productmolecular weight 269.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.