AZD3759

Catalog No. A15551

AZD3759是表皮生长因子受体（EGFR）的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。

Technical details

Catalog Num	A15551
M. Wt	459.9
Formula	C22H23ClFN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1626387-80-1
Synonyms	AZD 3759
SMILES	CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C

Biological Activity

AZD3759是表皮生长因子受体（EGFR）的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。

Targets

EGFR (L858R)	EGFR (exon 19Del)	EGFR (WT)
0.2 nM	0.2 nM	0.3 nM

Solubility *

In vitro	DMSO	80 mg/mL (173.94 mM)
	Water	Insoluble
	Ethanol	Warmed: 18 mg/mL (39.13 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.74 mL	108.72 mL	217.44 mL
0.5 mM	4.35 mL	21.74 mL	43.49 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
5 mM	0.43 mL	2.17 mL	4.35 mL

*The above data is based on the productmolecular weight 459.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.