DEL-22379

Catalog No. A15802

DEL-22379是一种有效的选择性ERK二聚体抑制剂，可抑制ERK二聚体而不影响ERK磷酸化，阻止由RAS-ERK途径癌基因驱动的肿瘤发生。

Technical details

Catalog Num	A15802
M. Wt	444.55
Formula	C26H28N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	181223-80-3
Synonyms	DEL22379, DEL 22379
SMILES	O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2C1=CC4=CNC5=CC=C(OC)C=C54

Biological Activity

DEL-22379是一种有效的选择性ERK二聚体抑制剂，可抑制ERK二聚体而不影响ERK磷酸化，阻止由RAS-ERK途径癌基因驱动的肿瘤发生。

Targets

ERK
0.5 μM

Solubility *

In vitro	DMSO	79 mg/mL (177.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.49 mL	112.47 mL	224.95 mL
0.5 mM	4.5 mL	22.49 mL	44.99 mL
1 mM	2.25 mL	11.25 mL	22.49 mL
5 mM	0.45 mL	2.25 mL	4.5 mL

*The above data is based on the productmolecular weight 444.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.