GSK2141795 (Uprosertib, GSK795)

Catalog No. A15809

GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。

Technical details

Catalog Num	A15809
M. Wt	429.25
Formula	C18H16Cl2F2N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1047634-65-0
Synonyms	GSK2141795, GSK2141795, Uprosertib, GSK 795
SMILES	CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl

Biological Activity

GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。

Targets

Akt3	Akt1	Akt2
38 nM	180 nM	328 nM

Solubility *

In vitro	DMSO	80 mg/mL (186.36 mM)
	Water	Insoluble
	Ethanol	80 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.3 mL	116.48 mL	232.96 mL
0.5 mM	4.66 mL	23.3 mL	46.59 mL
1 mM	2.33 mL	11.65 mL	23.3 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.