GZD824 Dimesylate

Catalog No. A15849

GZD824 Dimesylate是Bcr-Abl（WT）和Bcr-Abl（T315I）的新型生物可用Bcr-Abl抑制剂，IC50分别为0.34 nM和0.68 nM。

Technical details

Catalog Num	A15849
M. Wt	724.77
Formula	C29H27F3N6O.2CH4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1421783-64-3
Synonyms	GZD-824 Dimesylate
SMILES	CC1=CC=C(C(NC2=CC=C(CN3CCN(C)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=C5C(C=NN5)=C4.CS(=O)(O)=O.CS(=O)(O)=O

Biological Activity

GZD824 Dimesylate是Bcr-Abl（WT）和Bcr-Abl（T315I）的新型生物可用Bcr-Abl抑制剂，IC50分别为0.34 nM和0.68 nM。

Targets

Target	Value
Abl(Q252H)	IC50: 0.15nM
Abl(E255K)	IC50: 0.27nM
Abl(M351T)	IC50: 0.29nM
Abl	IC50: 0.34nM
Abl(H396P)	IC50: 0.35nM
Abl(Y253F)	IC50: 0.35nM
Abl(T315I)	IC50: 0.68nM
Abl(G250E)	IC50: 0.71nM

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (128.31 mM)
	Water	93 mg/mL (128.31 mM)
	Ethanol	Insoluble
In vivo	Saline	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.8 mL	68.99 mL	137.97 mL
0.5 mM	2.76 mL	13.8 mL	27.59 mL
1 mM	1.38 mL	6.9 mL	13.8 mL
5 mM	0.28 mL	1.38 mL	2.76 mL

*The above data is based on the productmolecular weight 724.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.