PRI-724

Catalog No. A15856

PRI-724是ICG-001的异构体或对映异构体，是一种强力的特异性抑制剂癌症干细胞中的Wnt信号通路具有潜在的抗肿瘤活性。

Product Citations

Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682

Technical details

Catalog Num	A15856
M. Wt	548.24
Formula	C33H32N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	847591-62-2
Synonyms	PRI 724, PRI724
SMILES	O=C(N(CC1)[C@](CN(CC2=C3C=CC=CC3=CC=C2)C([C@@H]4CC5=CC=C(O)C=C5)=O)([H])N4C1=O)NCC6=CC=CC=C6

Biological Activity

PRI-724是ICG-001的异构体或对映异构体，是一种强力的特异性抑制剂癌症干细胞中的Wnt信号通路具有潜在的抗肿瘤活性。

Targets

Wnt/β-catenin
150 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.24 mL	91.2 mL	182.4 mL
0.5 mM	3.65 mL	18.24 mL	36.48 mL
1 mM	1.82 mL	9.12 mL	18.24 mL
5 mM	0.36 mL	1.82 mL	3.65 mL

*The above data is based on the productmolecular weight 548.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.