PD0166285

Catalog No. A15863

PD0166285是一种有效的Wee1和Chk1抑制剂，在纳摩尔浓度下具有活性。PD0166285是一种新型的G2检查点消除剂。

Technical details

Catalog Num	A15863
M. Wt	512.43
Formula	C26H27Cl2N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	185039-89-8
Synonyms	PD-0166285, PD 0166285
SMILES	CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl

Biological Activity

PD0166285是一种有效的Wee1和Chk1抑制剂，在纳摩尔浓度下具有活性。PD0166285是一种新型的G2检查点消除剂。

Targets

Wee1	Myt1	Chk1
24 nM	72 nM	3.4 μM

Solubility *

In vitro	DMSO	91 mg/mL (177.58 mM)
	Water	Insoluble
	Ethanol	91 mg/mL (177.58 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.51 mL	97.57 mL	195.15 mL
0.5 mM	3.9 mL	19.51 mL	39.03 mL
1 mM	1.95 mL	9.76 mL	19.51 mL
5 mM	0.39 mL	1.95 mL	3.9 mL

*The above data is based on the productmolecular weight 512.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.