RSL3

Catalog No. A15865

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.

Product Citations

Sampilvanjil A, .et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
Samantha W. Alvarez, .et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506

Technical details

Catalog Num	A15865
M. Wt	440.88
Formula	C23H21ClN2O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1219810-16-8
Synonyms	1S,3R-RSL3
SMILES	COC(C1=CC=C([C@@]2([H])C3=C(C4=CC=CC=C4N3)C[C@](N2C(CCl)=O)([H])C(OC)=O)C=C1)=O

Biological Activity

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.

Targets

Gpx4

Solubility *

In vitro (25°C)	DMSO	82 mg/mL (185.99 mM)
	Water	Insoluble
	Ethanol	20 mg/mL
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.68 mL	113.41 mL	226.82 mL
0.5 mM	4.54 mL	22.68 mL	45.36 mL
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

*The above data is based on the productmolecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.