L-685458

Catalog No. A15899

L-685458是一种有效的A beta PPγ-分泌酶抑制剂，Ki为17 nM。

Technical details

Catalog Num	A15899
M. Wt	672.85
Formula	C39H52N4O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	292632-98-5
Synonyms	L685458, L 685458, L685,458
SMILES	O=C(OC(C)(C)C)N[C@H]([C@H](O)C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)=O)CC3=CC=CC=C3

Biological Activity

L-685458是一种有效的A beta PPγ-分泌酶抑制剂，Ki为17 nM。

Targets

Gamma-secretase
17 nM(Ki)

Solubility *

In vitro	DMSO	86 mg/mL (127.81 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (7.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.86 mL	74.31 mL	148.62 mL
0.5 mM	2.97 mL	14.86 mL	29.72 mL
1 mM	1.49 mL	7.43 mL	14.86 mL
5 mM	0.3 mL	1.49 mL	2.97 mL

*The above data is based on the productmolecular weight 672.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.