SirReal2

Catalog No. A15902

SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。

Product Citations

Yang Li, .et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 PMID: 29925042

Technical details

Catalog Num	A15902
M. Wt	420.55
Formula	C22H20N4OS2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	709002-46-0
Synonyms
SMILES	CC1=NC(SCC(NC2=NC=C(CC3=C(C=CC=C4)C4=CC=C3)S2)=O)=NC(C)=C1

Biological Activity

SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。

Targets

SIRT2
140 nM

Solubility *

In vitro	DMSO	Warmed: 71 mg/mL (168.82 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.78 mL	118.89 mL	237.78 mL
0.5 mM	4.76 mL	23.78 mL	47.56 mL
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

*The above data is based on the productmolecular weight 420.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.