A-1155463

Catalog No. A16112

A-1155463是一种高效且选择性强的BCL-XL抑制剂，A-1155463显示与BCL-XL的皮摩尔结合亲和力（Ki = <0.01 nM），与BCL-2的结合力弱1000倍以上（Ki = 80 nM）和相关蛋白BCL-W（Ki = 19 nM）和MCL-1（Ki> 440 nM）。

Product Citations

Daniel F R Boehmer, .et al. OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis, Sci Immunol, 2021, Jul 16;6(61) PMID: 34272227
Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

Technical details

Catalog Num	A16112
M. Wt	669.79
Formula	C35H32FN5O4S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1235034-55-5
Synonyms	A 1155463, A1155463
SMILES	O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O

Biological Activity

Targets

BCL-XL	Bcl-w	Bcl-2	Mcl-1
440 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	78 mg/mL (116.45 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.93 mL	74.65 mL	149.3 mL
0.5 mM	2.99 mL	14.93 mL	29.86 mL
1 mM	1.49 mL	7.47 mL	14.93 mL
5 mM	0.3 mL	1.49 mL	2.99 mL

*The above data is based on the productmolecular weight 669.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.