WNK463

Catalog No. A16205

WNK463是口服生物可用的泛WNK激酶抑制剂。

Product Citations

Lu DC, .et al. The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia, Pflugers Arch, 2019, Dec;471(11-12):1539-1549 PMID: 31729557

Technical details

Catalog Num	A16205
M. Wt	463.46
Formula	C21H24F3N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2012607-27-9
Synonyms	WNK-463, WNK 463
SMILES	CC(C)(C)NC(=O)C1=CN=CN1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F

Biological Activity

WNK463是口服生物可用的泛WNK激酶抑制剂。

Targets

WNK-kinase

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (174.77 mM)
	Water	Insoluble
	Ethanol	81 mg/mL (174.77 mM)
In vivo	5% DMSO+30%PEG 300+5% Tween 80+ddH2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.58 mL	107.88 mL	215.77 mL
0.5 mM	4.32 mL	21.58 mL	43.15 mL
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 463.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.