Pirfenidone

Catalog No. A16209

Pirfenidone是一种用于治疗特发性肺纤维化（IPF）的抗纤维化药物。它通过下调生长因子和前胶原I和II的产生来减少肺纤维化。

Technical details

Catalog Num	A16209
M. Wt	185.22
Formula	C12H11NO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	53179-13-8
Synonyms	AMR69, AMR-69, AMR 69
SMILES	O=C1C=CC(C)=CN1C2=CC=CC=C2

Biological Activity

Pirfenidone是一种用于治疗特发性肺纤维化（IPF）的抗纤维化药物。它通过下调生长因子和前胶原I和II的产生来减少肺纤维化。

Targets

TGF-β (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	37 mg/mL (199.76 mM)
	Water	Insoluble
	Ethanol	37 mg/mL (199.76 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	53.99 mL	269.95 mL	539.9 mL
0.5 mM	10.8 mL	53.99 mL	107.98 mL
1 mM	5.4 mL	26.99 mL	53.99 mL
5 mM	1.08 mL	5.4 mL	10.8 mL

*The above data is based on the productmolecular weight 185.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.