GW 441756

Catalog No. A16238

GW 441756是一种特异的肌球蛋白相关激酶A（TrkA）抑制剂，IC50值为2 nM。对c-Raf1和CDK2几乎没有活性。

Technical details

Catalog Num	A16238
M. Wt	275.31
Formula	C17H13N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	504433-23-2
Synonyms	GW-441756, GW441756
SMILES	O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4

Biological Activity

GW 441756是一种特异的肌球蛋白相关激酶A（TrkA）抑制剂，IC50值为2 nM。对c-Raf1和CDK2几乎没有活性。

Targets

TrkA	CDK2	C-Raf-1
2 nM	>7 μM	>12 μM

Solubility *

In vitro	DMSO	25 mg/mL (90.81 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.32 mL	181.61 mL	363.23 mL
0.5 mM	7.26 mL	36.32 mL	72.65 mL
1 mM	3.63 mL	18.16 mL	36.32 mL
5 mM	0.73 mL	3.63 mL	7.26 mL

*The above data is based on the productmolecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.