LY2835219 methanesulfonate

Catalog No. A16386

LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。

Technical details

Catalog Num	A16386
M. Wt	602.7
Formula	C27H32F2N8.CH4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1231930-82-7
Synonyms	Abemaciclib
SMILES	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

Biological Activity

LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (134.39 mM)
	Water	97 mg/mL (160.94 mM)
	Ethanol	23 mg/mL
In vivo	water	95 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.59 mL	82.96 mL	165.92 mL
0.5 mM	3.32 mL	16.59 mL	33.18 mL
1 mM	1.66 mL	8.3 mL	16.59 mL
5 mM	0.33 mL	1.66 mL	3.32 mL

*The above data is based on the productmolecular weight 602.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

LY2835219 methanesulfonate

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions