Niraparib tosylate

Catalog No. A16618

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.

Product Citations

Laurie B Schenkel, .et al. A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants, Cell Chem Biol, 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33705687

Technical details

Catalog Num	A16618
M. Wt	492.59
Formula	C26H28N4O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1038915-73-9
Synonyms	MK-4827 tosylate
SMILES	NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O

Biological Activity

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.

Solubility *

In vitro	DMSO	86 mg/mL (174.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.3 mL	101.5 mL	203.01 mL
0.5 mM	4.06 mL	20.3 mL	40.6 mL
1 mM	2.03 mL	10.15 mL	20.3 mL
5 mM	0.41 mL	2.03 mL	4.06 mL

*The above data is based on the productmolecular weight 492.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.