Oclacitinib maleate

Catalog No. A16640

Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM).

Product Citations

Carlos H de Mello Souza, .et al. Cytokine production and the effects of oclacitinib in three canine mast cell tumour cell lines, Vet Dermatol, 2021, Dec 9 PMID: 34882871

Technical details

Catalog Num	A16640
M. Wt	453.51
Formula	C19H27N5O6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1640292-55-2
Synonyms	PF-03394197 maleate
SMILES	O=S(C[C@H]1CC[C@H](N(C)C2=C3C(NC=C3)=NC=N2)CC1)(NC)=O.O=C(O)/C=C\C(O)=O

Biological Activity

Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM).

Solubility *

In vitro	DMSO	81 mg/mL (178.61 mM)
	Water	16 mg/mL (35.28 mM)
	Ethanol	81 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.25 mL	220.5 mL
0.5 mM	4.41 mL	22.05 mL	44.1 mL
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL

*The above data is based on the productmolecular weight 453.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.