Atuveciclib (BAY-1143572)

Catalog No. A16810

Atuveciclib (BAY-1143572)是目前处于I期的PTEFb/CDK9的高度选择性，有效且可口服的抑制剂。

Product Citations

Cole Schonhofer, .et al. Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency, Biochem Pharmacol, 2021, Apr;186:114462 PMID: 33577894

Technical details

Catalog Num	A16810
M. Wt	387.43
Formula	C18H18FN5O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1414943-88-6
Synonyms	BAY 1143572, BAY-1143572
SMILES	O=S(C)(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)=N

Biological Activity

Atuveciclib (BAY-1143572)是目前处于I期的PTEFb/CDK9的高度选择性，有效且可口服的抑制剂。

Solubility *

In vitro	DMSO	69 mg/mL (178.09 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.81 mL	129.06 mL	258.11 mL
0.5 mM	5.16 mL	25.81 mL	51.62 mL
1 mM	2.58 mL	12.91 mL	25.81 mL
5 mM	0.52 mL	2.58 mL	5.16 mL

*The above data is based on the productmolecular weight 387.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.