Lazertinib (YH25448,GNS-1480)
Catalog No. A16827
Lazertinib (YH25448,GNS-1480)是一种有效的，高度突变选择性和不可逆的EGFR-TKI，对于Del19/T790M，L858R/T790M，Del19，Del19，IC50值分别为1.7 nM，2 nM，5 nM，20.6 nM和76 nM。L85R和野生型EGFR分别显示出更高的IC50值，即抗药性ErbB2和ErbB4。
| Catalog Num | A16827 |
|---|---|
| M. Wt | 554.66 |
| Formula | C30H34N8O3 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1903008-80-9 |
| Synonyms | YH 25448, YH-25448, GNS1480, GNS 1480 |
| SMILES | C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O |
Lazertinib (YH25448,GNS-1480)是一种有效的，高度突变选择性和不可逆的EGFR-TKI，对于Del19/T790M，L858R/T790M，Del19，Del19，IC50值分别为1.7 nM，2 nM，5 nM，20.6 nM和76 nM。L85R和野生型EGFR分别显示出更高的IC50值，即抗药性ErbB2和ErbB4。
| In vitro | DMSO | 4 mg/mL (7.21 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.15 mL | 180.29 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
*The above data is based on the productmolecular weight 554.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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