MK-8353 (SCH900353)

Catalog No. A16838

MK-8353 (SCH900353)是一种口服生物利用型，选择性和有效的ERK抑制剂，在体外抑制激活的ERK1和ERK2，IC50值分别为23.0 nM和8.8 nM（IMAP激酶测定），以及未激活的ERK2，具有IC50值 0.5 nM（MEK1-ERK2耦合测定）。

Technical details

Catalog Num	A16838
M. Wt	691.84
Formula	C37H41N9O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1184173-73-6
Synonyms	MK8353, MK 8353, SCH 900353, SCH-900353
SMILES	O=C(CN1CC[C@@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5

Solubility *

In vitro	DMSO	45 mg/mL (65.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.45 mL	72.27 mL	144.54 mL
0.5 mM	2.89 mL	14.45 mL	28.91 mL
1 mM	1.45 mL	7.23 mL	14.45 mL
5 mM	0.29 mL	1.45 mL	2.89 mL

*The above data is based on the productmolecular weight 691.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

MK-8353 (SCH900353)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions