PF-06873600
Catalog No. A16875
PF-06873600是一种口服生物利用型，细胞周期蛋白依赖性激酶（CDK）抑制剂，其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。
- Abeer J Al-Qasem, .et al. Co-targeting CDK2 and CDK4/6 overcomes resistance to aromatase and CDK4/6 inhibitors in ER+ breast cancer, NPJ Precis Oncol, 2022, Sep 24;6(1):68 PMID: 36153348
| Catalog Num | A16875 |
|---|---|
| M. Wt | 471.52 |
| Formula | C20H27F2N5O4S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2185857-97-8 |
| Synonyms | PF 06873600, PF06873600 |
| SMILES | O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4 |
PF-06873600是一种口服生物利用型，细胞周期蛋白依赖性激酶（CDK）抑制剂，其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.21 mL | 106.04 mL | 212.08 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.42 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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